Language
English
Publication Date
2-27-2023
Journal
Biochemical Society Transactions
DOI
10.1042/BST20220455
PMID
36744642
PMCID
PMC10518207
PubMedCentral® Posted Date
2-27-2024
PubMedCentral® Full Text Version
Author MSS
Abstract
How organisms learn and encode memory is an outstanding question in neuroscience research. Specifically, how memories are acquired and consolidated at the level of molecular and gene pathways remains unclear. In addition, memory is disrupted in a wide variety of neurological disorders; therefore, discovering molecular regulators of memory may reveal therapeutic targets for these disorders. C. elegans are an excellent model to uncover molecular and genetic regulators of memory. Indeed, the nematode's invariant neuronal lineage, fully mapped genome, and conserved associative behaviors have allowed the development of a breadth of genetic and genomic tools to examine learning and memory. In this mini-review, we discuss novel and exciting genetic and genomic techniques used to examine molecular and genetic underpinnings of memory from the level of the whole-worm to tissue-specific and cell-type specific approaches with high spatiotemporal resolution.
Keywords
Animals, Caenorhabditis elegans, Learning, Caenorhabditis elegans Proteins, Genome, Genomics
Published Open-Access
yes
Recommended Citation
, "Uncovering Novel Regulators of Memory Using C elegans Genetic and Genomic Analysis" (2023). Faculty, Staff and Students Publications. 1905.
https://digitalcommons.library.tmc.edu/baylor_docs/1905