Language
English
Publication Date
5-15-2023
Journal
Cancer Research
DOI
10.1158/0008-5472.CAN-23-0296
PMID
36946612
PMCID
PMC10183808
PubMedCentral® Posted Date
3-22-2023
PubMedCentral® Full Text Version
Post-print
Abstract
Extensive studies have focused on the misregulation of individual miRNAs in cancer. More recently, mutations in the miRNA biogenesis and processing machinery have been implicated in several malignancies. Such mutations can lead to global miRNA misregulation, which may promote many of the well-known hallmarks of cancer. Interestingly, recent evidence also suggests that oncogenic Kristen rat sarcoma viral oncogene homolog (KRAS) mutations act in part by modulating the activity of members of the miRNA regulatory pathway. Here, we highlight the vital role mutations in the miRNA core machinery play in promoting malignant transformation. Furthermore, we discuss how mutant KRAS can simultaneously impact multiple steps of miRNA processing and function to promote tumorigenesis. Although the ability of KRAS to hijack the miRNA regulatory pathway adds a layer of complexity to its oncogenic nature, it also provides a potential therapeutic avenue that has yet to be exploited in the clinic. Moreover, concurrent targeting of mutant KRAS and members of the miRNA core machinery represents a potential strategy for treating cancer.
Keywords
Humans, Cell Transformation, Neoplastic, MicroRNAs, Mutation, Neoplasms, Proto-Oncogene Proteins p21(ras)
Published Open-Access
yes
Recommended Citation
, "KRAS Hijacks the miRNA Regulatory Pathway in Cancer" (2023). Faculty, Staff and Students Publications. 2050.
https://digitalcommons.library.tmc.edu/baylor_docs/2050