Language

English

Publication Date

6-1-2026

Journal

Journal of Clinical Psychology in Medical Settings

DOI

10.1007/s10880-025-10092-2

PMID

40813548

PMCID

PMC13226408

PubMedCentral® Posted Date

8-14-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Between 60 and 80% of adults with osteogenesis imperfecta (OI) experience chronic pain and associated interference. Currently available pain therapies often provide marginal efficacy. Mindful self-compassion (MSC) has emerged as a promising intervention for coping with chronic pain. We conducted a single-center 8-week pilot intervention study to assess the feasibility and acceptability of a MSC program among adults with OI and co-occurring chronic pain. Individuals attended the validated MSC course consisting of 8 weekly virtual 2-h sessions. Participants completed a battery of validated questionnaires assessing pain, various aspects of well-being, and physical function at baseline and post-intervention. Participants wore the ActiGraph GT9X Link watch to measure sleep duration and sleep efficiency. Seven adults with OI and co-occurring pain participated in the MSC program. The program was feasible, as indicated by high attendance and high questionnaire completion rates. Participants reported a mean ± standard deviation (SD) of 3.5 out of 5 ± 0.4 on the Intervention Acceptability Framework. 86% (6/7) of participants found the MSC program to be acceptable. While our pilot study was not powered to show efficacy, we observed a decrease in pain interference on the PROMIS pain interference questionnaire (mean 55.9 ± 5.5 at baseline vs. 50.0 ± 7.3 at 8 weeks). Implementation of the MSC program is feasible as a potential therapeutic option to address chronic pain in OI.

Keywords

Humans, Osteogenesis Imperfecta, Female, Adult, Pilot Projects, Male, Chronic Pain, Middle Aged, Mindfulness, Empathy, Feasibility Studies, Pain Management, Surveys and Questionnaires, Osteogenesis imperfecta, Pain, Mindful self-compassion, Chronic disease, Positive psychology

Published Open-Access

yes

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