Language
English
Publication Date
6-30-2026
Journal
Head and Neck Pathology
DOI
10.1007/s12105-026-01948-6
PMID
42377639
PMCID
PMC13319277
PubMedCentral® Posted Date
6-30-2026
PubMedCentral® Full Text Version
Post-print
Abstract
Intraductal carcinoma (IDC) of the salivary gland is an uncommon epithelial neoplasm characterized by a predominantly intraductal or intracystic proliferation rimmed by a myoepithelial cell layer. Advances in molecular profiling have revealed recurrent gene fusions in IDC, most frequently involving RET, although fusions implicating other kinase genes have also been described. Among these, ALK rearrangements are rare and remain poorly characterized. Herein, we report a case of oncocytic IDC of the parotid gland harboring a STRN::ALK fusion, further expanding the molecular landscape of this tumor. Although this fusion has been previously reported in intercalated duct IDC, to our knowledge, this is the first report of this specific fusion in oncocytic IDC.
Keywords
Humans, Parotid Neoplasms, Anaplastic Lymphoma Kinase, Carcinoma, Intraductal, Noninfiltrating, Female, Neoplasm Proteins, Carcinoma, Ductal, Calmodulin-Binding Proteins, Membrane Proteins, Nerve Tissue Proteins, Salivary gland, intraductal carcinoma, ALK fusion, STRN gene, RNA sequencing
Published Open-Access
yes
Recommended Citation
Soliman, Reham H; Shi, Chris; Fisher, Kevin E; et al., "Oncocytic Intraductal Carcinoma of the Parotid Gland with STRN::ALK Fusion" (2026). Faculty, Staff and Students Publications. 7487.
https://digitalcommons.library.tmc.edu/baylor_docs/7487