Language
English
Publication Date
7-1-2024
DOI
10.1542/peds.2023-064048
PMID
38864107
PMCID
PMC11287934
PubMedCentral® Posted Date
7-1-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
A 4-month-old full-term female presented with growth faltering associated with progressive feeding difficulty, rash, abdominal distension, and developmental delays. She was found to have disconjugate gaze, abnormal visual tracking, mixed tone, bruising, and splenomegaly on examination. Initial workup was notable for thrombocytopenia and positive cytomegalovirus (CMV) immunoglobulin G and immunoglobulin M antibodies. She initially presented to the infectious diseases CMV clinic, where she was noted to have severe malnutrition, prompting referral to the emergency department for hospital admission to optimize nutrition with nasogastric tube feeding and facilitate additional evaluation. An active CMV infection with viruria and viremia was confirmed, but elements of her presentation and workup including brain magnetic resonance imaging were not consistent with isolated CMV infection. To avoid premature diagnostic closure, a multidisciplinary workup was initiated and ultimately established her diagnosis.
Keywords
Humans, Female, Infant, Splenomegaly, Thrombocytopenia, Cytomegalovirus Infections, Failure to Thrive, Diagnosis, Differential
Published Open-Access
yes
Recommended Citation
Barak, Gal; Demmler-Harrison, Gail; Rossetti, Linda; et al., "Progressive Thrombocytopenia, Splenomegaly, and Abnormal Tone in an Infant With Growth Faltering" (2024). Faculty, Staff and Students Publications. 7611.
https://digitalcommons.library.tmc.edu/baylor_docs/7611