Anterior Cutaneous Nerve Entrapment Syndrome From Glucagon-Like Peptide-1 Receptor Agonist Injection

Authors

• Neha Singh
• Elisa Chaparro
• Jordan Michael Shapiro
• Emanuel Narcis Husu

Language

English

Publication Date

6-1-2026

Journal

ACG Case Reports Journal

DOI

10.14309/crj.0000000000002168

PMID

42326458

PMCID

PMC13282047

PubMedCentral® Posted Date

6-19-2026

PubMedCentral® Full Text Version

Post-print

Abstract

Anterior cutaneous nerve entrapment syndrome (ACNES) is an underdiagnosed cause of abdominal pain. We report the first documented ACNES case following subcutaneous administration of glucagon-like peptide-1 receptor agonist. A 44-year-old man developed focal, neuropathic abdominal pain coinciding with initiation of tirzepatide injections. Clinical examination confirmed ACNES diagnosis, and pain improved after relocating injections away from the abdomen and initiating multimodal pharmacotherapy. This case emphasizes the need to consider ACNES in patients endorsing focal abdominal pain with concurrent use of glucagon-like peptide-1 therapy and highlights injection site modification as a simple, effective management strategy while exercising self-restraint with respect to workup.

Keywords

abdominal pain, glucagon-like peptide-1 receptor agonist, GLP-1 receptor agonist

Published Open-Access

yes

Recommended Citation

Singh, Neha; Chaparro, Elisa; Shapiro, Jordan Michael; et al., "Anterior Cutaneous Nerve Entrapment Syndrome From Glucagon-Like Peptide-1 Receptor Agonist Injection" (2026). Faculty, Staff and Students Publications. 7781.
https://digitalcommons.library.tmc.edu/baylor_docs/7781