Language
English
Publication Date
4-1-2025
Journal
Nature
DOI
10.1038/s41586-025-08790-w
PMID
40205214
PMCID
PMC11981939
PubMedCentral® Posted Date
4-9-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Understanding the brain requires understanding neurons' functional responses to the circuit architecture shaping them. Here we introduce the MICrONS functional connectomics dataset with dense calcium imaging of around 75,000 neurons in primary visual cortex (VISp) and higher visual areas (VISrl, VISal and VISlm) in an awake mouse that is viewing natural and synthetic stimuli. These data are co-registered with an electron microscopy reconstruction containing more than 200,000 cells and 0.5 billion synapses. Proofreading of a subset of neurons yielded reconstructions that include complete dendritic trees as well the local and inter-areal axonal projections that map up to thousands of cell-to-cell connections per neuron. Released as an open-access resource, this dataset includes the tools for data retrieval and analysis
Keywords
Animals, Mice, Connectome, Visual Cortex, Synapses, Neurons, Male, Primary Visual Cortex, Calcium, Female, Dendrites, Mice, Inbred C57BL, Axons
Published Open-Access
yes
Recommended Citation
The MICrONS Consortium, "Functional Connectomics Spanning Multiple Areas of Mouse Visual Cortex" (2025). Faculty, Staff and Students Publications. 7953.
https://digitalcommons.library.tmc.edu/baylor_docs/7953