Language
English
Publication Date
1-1-2026
Journal
Frontiers in Cell and Developmental Biology
DOI
10.3389/fcell.2026.1769372
PMID
41890906
PMCID
PMC13013432
PubMedCentral® Posted Date
3-11-2026
PubMedCentral® Full Text Version
Post-print
Abstract
Neuroblastoma (NB), a pediatric malignancy of the peripheral nervous system, accounts for 15% of pediatric cancer deaths and remains a major challenge for cancer therapy. NB originates from sympathoadrenal (SA) progenitors of the neural crest (NC) cell lineage, whose formation and differentiation are controlled by epigenetic mechanisms. Although signaling pathways and epigenetic factors implicated in NB tumorigenesis have been well-described, a holistic understanding of how development and epigenetics overlap to drive NB is lacking. By exploring vital interplays and co-dependencies between key pathways and their epigenetic control in NC development, we have gained novel insights into the mechanisms governing NB differentiation and oncogenesis. These converging insights have enabled the application of targeted therapies against epigenetic regulators driving NB with promising implications for patient outcomes.
Keywords
pigenetics, neural crest, neuroblastoma, oncogenesis, tumor microenvironment
Published Open-Access
yes
Recommended Citation
Drolet, Nathan; Wolf, Amber; Yi, Joanna; et al., "Epigenetic Crosstalk in Neuroblastoma Development and Progression" (2026). Faculty, Staff and Students Publications. 7976.
https://digitalcommons.library.tmc.edu/baylor_docs/7976