Language

English

Publication Date

11-1-2023

Journal

The Journal of Biomechanics

DOI

10.1016/j.jbiomech.2023.111825

PMID

37856976

PMCID

PMC10991081

PubMedCentral® Posted Date

5-25-2024

PubMedCentral® Full Text Version

Author MSS

Abstract

Patients with psoriatic arthritis commonly have abnormalities of their entheses, which are the connections between tendons and bone. There are shortcomings with the use of conventional magnetic resonance imaging (MRI) sequences for the evaluation of entheses and tendons, whereas ultrashort echo time (UTE) sequences are superior for the detection of high signals, and can also be used for non-invasive quantitative assessments of these structures. The combination of UTE-MRI with an adiabatic-T1ρ preparation (UTE-Adiab-T1ρ) allows for reliable assessment of entheses and tendons with decreased susceptibility to detrimental magic angle effects. This study aimed to investigate the relationship between quantitative UTE-MRI measures and the biomechanical properties of Achilles tendons and entheses. In total, 28 tendon-enthesis sections were harvested from 11 fresh-frozen human cadaveric foot-ankle specimens (52±years old). Tendon-enthesis sections were scanned using the UTE-Adiab-T1ρ and UTE-T1 sequences on a clinical 3T scanner. MRI-based measures and indentation tests were performed on the enthesis, transitional, and tensile tendon zones of the specimens. Hayes’ elastic modulus showed significant inverse correlations (Spearman’s) with UTE-Adiab-T1ρ in all zones (R= − 0.46, − 0.54, and − 0.61 in enthesis, transition, and tensile tendon zones, respectively). Oliver-Pharr’s elastic modulus showed significant inverse correlations with UTE-Adiab-T1ρ in transition (R= − 0.52) and tensile tendon zone (R=− 0.60). UTE-T1 did not show significant correlations with the elastic modulus. UTE-MRI and elastic modulus were significantly lower in the tensile tendon compared with the enthesis regions This study highlights the potential of the UTE-Adiab-T1ρ technique for the non-invasive evaluation of tendons and entheses.

Keywords

Humans, Achilles Tendon, Magnetic Resonance Imaging, Middle Aged, Elastic Modulus, Male, Female, Biomechanical Phenomena, Adult, Arthritis, Psoriatic

Published Open-Access

yes

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