Language
English
Publication Date
8-16-2025
Journal
Nature Communications
DOI
10.1038/s41467-025-62999-x
PMID
40819134
PMCID
PMC12357870
PubMedCentral® Posted Date
8-16-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Designing efficient, biocompatible radiation-sensitive materials to activate systemic immune responses can maximize tumoricidal effects against malignant tumors. Here, inspired by natural Mn-peroxidase, we propose the de novo design of the RuMn-oxygen complex (MnBTC-Ru) for biocatalytic and radiosensitization therapies to eradicate primary and metastatic tumors. Our results reveal that Mn-organic ligands can enhance the electron density of Ru clusters, thereby optimizing their binding to oxygen species and resulting in high reactive oxygen species and oxygen generation. Accordingly, MnBTC-Ru with radiation can enhance cell membrane and DNA damage, triggering apoptosis though oxidative damage, heightening radiosensitization, and activating CD8
Keywords
Animals, Mice, Female, Radiation-Sensitizing Agents, Ruthenium, Oxygen, Manganese, Cell Line, Tumor, Humans, Reactive Oxygen Species, Neoplasms, Biocatalysis, Apoptosis, Coordination Complexes, CD8-Positive T-Lymphocytes, Neoplasm Metastasis, DNA Damage, Nanotechnology in cancer, Nanoparticles, Nanocomposites, Nanostructures
Published Open-Access
yes
Recommended Citation
Li, Ruidan; Wang, Ting; Mu, Shengdong; et al., "Bioinspired Ruthenium-Manganese-Oxygen Complex for Biocatalytic and Radiosensitization Therapies To Eradicate Primary and Metastatic Tumors" (2025). Faculty, Staff and Students Publications. 7993.
https://digitalcommons.library.tmc.edu/baylor_docs/7993