Language
English
Publication Date
7-26-2026
Journal
Viruses
DOI
10.3390/v18080823
PMID
42655643
PMCID
PMC13517826
PubMedCentral® Posted Date
7-26-2026
PubMedCentral® Full Text Version
Post-print
Abstract
Since emerging in late 2019, SARS-CoV-2 has caused over 7 million deaths globally and remains a public health concern. Understanding SARS-CoV-2 pathogenesis is vital, especially as factors like environmental exposures are still poorly understood. Polycyclic aromatic hydrocarbons (PAHs), like benzo[a]pyrene (BP), found in pollutants like cigarette smoke, diesel exhaust, and charcoal-broiled steaks, are known to injure the lungs. We aimed to evaluate if BP exacerbates SARS-CoV-2 pathogenesis in a mouse model of disease. One day following intranasal administration of BP (20 mg/kg) or vehicle control, we infected male and female K18-hACE2 mice with ancestral SARS-CoV-2 and assessed lung viral load, weight change, clinical scores, immune cell recruitment, and survival in the presence and absence of BP exposure. We found that BP-exposed mice had decreased survival compared to mock-exposed mice. Additionally, BP did not alter innate or adaptive immune cell populations in the lungs of SARS-CoV-2-infected mice. These findings suggest that PAH exposure exacerbates severe COVID-19 outcomes by unknown mechanisms, highlighting the need to further explore environmental impacts on SARS-CoV-2 infection.
Keywords
Animals, Mice, Disease Models, Animal, Male, Female, SARS-CoV-2, Benzo(a)pyrene, COVID-19, Lung, Viral Load, Polycyclic Aromatic Hydrocarbons, Humans, SARS-CoV-2, pollutant, environmental exposure, murine models
Published Open-Access
yes
Recommended Citation
Spencer Clinton, Jennifer L; Green, Freedom M; Crotty, Emma E; et al., "The Environmental Polycyclic Aromatic Hydrocarbon (PAH) Benzo[a]pyrene (BP) Alters SARS-CoV-2 Pathogenesis in a Mouse Model of Disease" (2026). Faculty, Staff and Students Publications. 8177.
https://digitalcommons.library.tmc.edu/baylor_docs/8177