Language
English
Publication Date
2-5-2025
Journal
Endocrinology
DOI
10.1210/endocr/bqaf032
PMID
39950970
PMCID
PMC11843549
PubMedCentral® Posted Date
2-14-2025
PubMedCentral® Full Text Version
Post-print
Abstract
The uterus is a complex organ that requires precise signaling networks to mediate functions necessary for homeostasis and reproductive processes. The transforming growth factor β (TGFβ) superfamily regulates integral signaling pathways throughout many physiological processes, including cell proliferation, differentiation, and development. In this review, we summarize the current understanding of how the TGFβ signaling family controls key uterine functions, with a specific focus on the endometrium. These uterine functions include endometrial receptivity, implantation, decidualization, placentation, remodeling, and regeneration. Improving our understanding of the signaling networks that regulate these processes is integral to identifying, diagnosing, and treating uterine and reproductive diseases such as endometriosis, adenomyosis, recurrent pregnancy loss, and recurrent implantation failure.
Keywords
Humans, Female, Signal Transduction, Transforming Growth Factor beta, Uterus, Animals, Pregnancy, Embryo Implantation, Endometrium, Uterine Diseases, uterus, endometrium, TGFβ signaling, uterine disease, endometriosis
Published Open-Access
yes
Recommended Citation
Anna Catherine Unser and Diana Monsivais, "Integral Roles of the TGFβ Signaling Pathway in Uterine Function and Disease" (2025). Faculty, Staff and Students Publications. 8182.
https://digitalcommons.library.tmc.edu/baylor_docs/8182