Language

English

Publication Date

1-1-2026

Journal

Internal Medicine

DOI

10.2169/internalmedicine.5558-25

PMID

40467512

PMCID

PMC12854949

PubMedCentral® Posted Date

6-5-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Central diabetes insipidus (CDI) can develop as an acquired systemic disease. However, cases of eosinophilic granulomatosis with polyangiitis (EGPA) with concurrent CDI are rare. We herein report a case of EGPA following CDI. A 68-year-old woman with a 30-year history of sinusitis and asthma developed CDI, followed by severe renal dysfunction with eosinophilia and elevated myeloperoxidase-antineutrophil cytoplasmic antibody levels. A renal biopsy confirmed EGPA. Intensive treatment resulted in dialysis discontinuation, while partial improvement in arginine vasopressin secretion suggested a potential link between EGPA and CDI. We also conducted a literature review on concurrent EGPA and CDI. Clinicians should be aware of EGPA in CDI patients with asthma or sinusitis.

Keywords

Humans, Female, Aged, Granulomatosis with Polyangiitis, Diabetes Insipidus, Neurogenic, Antibodies, Antineutrophil Cytoplasmic, Asthma, eosinophilic granulomatosis with polyangiitis, EGPA, central diabetes insipidus, CDI, acute kidney injury, dialysis

Published Open-Access

yes

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