Language
English
Publication Date
1-1-2024
Journal
Vitamins and Hormones
DOI
10.1016/bs.vh.2023.05.003
PMID
38408801
PMCID
PMC11023618
PubMedCentral® Posted Date
4-17-2024
PubMedCentral® Full Text Version
Author MSS
Abstract
Mouse models have been widely used in the study of adrenal gland development and diseases. The X-zone is a unique structure of the mouse adrenal gland and lineage-tracing studies show that the X-zone is a remnant of the fetal adrenal cortex. Although the X-zone is considered analogous to the fetal zone in the human adrenal cortex, the functional significance of the X-zone has remained comparatively more obscure. The X-zone forms during the early postnatal stages of adrenal development and regresses later in a remarkable sexually dimorphic fashion. The formation and regression of the X-zone can be different in mice with different genetic backgrounds. Mouse models with gene mutations, hormone/chemical treatments, and/or gonadectomy can also display an aberrant development of the X-zone or alternatively a dysregulated X-zone regression. These models have shed light on the molecular mechanisms regulating the development and regression of these unique adrenocortical cells. This review paper briefly describes the development of the adrenal gland including the formation and regression processes of the X-zone. It also summarizes and lists mouse models that demonstrate different X-zone phenotypes.
Keywords
Mice, Humans, Animals, Adrenal Glands, Adrenal Cortex, Adrenal Cortex Neoplasms, Adrenal gland, X-zone
Published Open-Access
yes
Recommended Citation
Kang, Yuan; Laprocina, Karly; Zheng, Huifei Sophia; et al., "Current Insight Into the Transient X-Zone in the Adrenal Gland Cortex" (2024). Faculty, Staff and Students Publications. 8377.
https://digitalcommons.library.tmc.edu/baylor_docs/8377