Language
English
Publication Date
12-18-2024
Journal
The Journal of Clinical Endocrinology & Metabolism
DOI
10.1210/clinem/dgae392
PMID
38870260
PMCID
PMC11651699
PubMedCentral® Posted Date
6-13-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Context: Patients with nonfunctioning adenomas (NFAs), adenomas with mild autonomous cortisol secretion (MACS) and Cushing syndrome (CS) demonstrate an increased cardiovascular risk.
Objective: This work aimed to determine the extent of lipoprotein abnormalities in NFA, MACS, and CS.
Methods: We conducted a single-center, cross-sectional study of patients with NFA (n = 167), MACS (n = 213), CS (n = 142), and referent individuals (n = 202) between January 2015 and July 2022. Triglyceride-rich lipoprotein particles (TRLP), low-density lipoprotein particles (LDLP), high-density lipoprotein particles (HDLP), their subclasses and sizes were measured using nuclear magnetic resonance spectroscopy. Multivariable logistic analyses were adjusted for age, sex, body mass index, smoking, hypertension, diabetes and lipid-lowering drug therapy.
Results: In age- and sex-adjusted analysis, all patients categories demonstrated increased very large TRLP, large TRLP, and greater TRLP size (odds ratio [OR], 1.22-2.08) and total LDLP (OR, 1.22-1.75) and decreased LDL and HDL size compared to referent individuals. In fully adjusted analysis, LDLP concentrations remained elevated in all patient categories (OR, 1.31-1.84). Total cholesterol, LDL cholesterol, triglycerides, and apolipoprotein B (ApoB) were also higher in all patient categories in age- and sex-adjusted analysis, with ApoB remaining elevated in all patient categories in fully adjusted analysis. Similar LDLP and ApoB elevations were observed in all patient categories after excluding individuals on lipid-lowering therapy.
Conclusion: Patients with overt, mild, and even absent cortisol excess demonstrate lipoprotein profile abnormalities, in particular, high LDLP and ApoB concentrations, which conceivably contribute to high cardiometabolic risk.
Keywords
Humans, Female, Male, Middle Aged, Cross-Sectional Studies, Adult, Lipoproteins, LDL, Adrenal Cortex Neoplasms, Adrenocortical Adenoma, Apolipoprotein B-100, Cushing Syndrome, Aged, Triglycerides, Apolipoproteins B, MACS, mild autonomous cortisol secretion, cortisol, Cushing syndrome, lipoprotein particle, nuclear magnetic resonance spectroscopy
Published Open-Access
yes
Recommended Citation
Sandooja, Rashi; Saini, Jasmine; Kittithaworn, Annop; et al., "High LDL Particle and APOB Concentrations in Patients With Adrenal Cortical Adenomas" (2024). Faculty, Staff and Students Publications. 8388.
https://digitalcommons.library.tmc.edu/baylor_docs/8388