Language
English
Publication Date
8-1-2026
Journal
Journal of the Endocrine Society
DOI
10.1210/jendso/bvag104
PMID
42491361
PMCID
PMC13376676
PubMedCentral® Posted Date
5-2-2026
PubMedCentral® Full Text Version
Post-print
Abstract
Context: Bilateral adrenalectomy (BLA) and autoimmune adrenal insufficiency (AAI) are 2 major causes of primary adrenal insufficiency (PAI). Comparative data between etiologies are limited.
Objective: To compare management, quality of life (QoL), and frequency of adrenal crises between participants post-BLA vs AAI.
Methods: We conducted a dual-center, cross-sectional study of adults with AAI or BLA between 2018 and 2025. All participants completed questionnaires on management, adrenal crises, and the Addison Disease-specific QoL Questionnaire (AddiQoL).
Results: Of 343 participants, 203 had AAI (median age 54 years, 72% women) and 139 had BLA (median age 57 years, 76% women). AddiQoL scores were similar between participants with AAI and BLA (median 84 vs 83, P = .947), but better in participants post-BLA for pheochromocytoma versus hypercortisolism (median 88 vs 81, P = .031). Participants with AAI reported a higher number of adrenal crises within the past year than those post-BLA (25% vs 13%, P = .022). In multivariable analyses of age, sex, glucocorticoid dose and type, PAI type, AddiQoL score, and autoimmune comorbidities, only PAI type was associated with higher number of reported adrenal crisis within the last year (AAI vs BLA: odds ratios of 2.1-2.2, P < .05 for all models).
Conclusion: QoL was comparable between participants with AAI and BLA, though patients post-BLA for pheochromocytoma reported better QoL than patients post-BLA for hypercortisolism. Adrenal crises were more common in participants with AAI than those post-BLA, a finding that was not explained by patients' glucocorticoid management, underscoring the need for tailored crisis prevention strategies.
Keywords
AI, PAI, BLA, AA, AAI, AddiQoL, QoL, management
Published Open-Access
yes
Recommended Citation
Bancos, Alexandra N; Gregg-Garcia, Raul; Genere, Natalia; et al., "Adrenal Crises and Quality of Life After Bilateral Adrenalectomy vs Primary Autoimmune Adrenal Insufficiency" (2026). Faculty, Staff and Students Publications. 8431.
https://digitalcommons.library.tmc.edu/baylor_docs/8431