Language
English
Publication Date
2-19-2024
Journal
bioRxiv
DOI
10.1101/2024.02.15.580454
PMID
38464008
PMCID
PMC10925092
PubMedCentral® Posted Date
2-19-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Rhamnose is an essential component of the plant cell wall and is synthesized from uridine diphosphate (UDP)-glucose by the RHAMNOSE1 (RHM1) enzyme. RHM1 localizes to biomolecular condensates in plants, but their identity, formation, and function remain elusive. Combining live imaging, genetics, and biochemical approaches in Arabidopsis and heterologous systems, we show that RHM1 alone is sufficient to form enzymatically active condensates, which we name rhamnosomes. Rhamnosome formation is required for UDP-rhamnose synthesis and organ development. Overall, our study demonstrates a novel role for biomolecular condensation in metabolism and organismal development, and provides further support for how organisms have harnessed this biophysical process to regulate small molecule metabolism.
Published Open-Access
yes
Recommended Citation
Field, Sterling; Dorone, Yanniv; Dwyer, Will P; et al., "Arabidopsis Thaliana RHAMNOSE 1 Condensate Formation Drives UDP-Rhamnose Synthesis" (2024). Faculty, Staff and Students Publications. 8542.
https://digitalcommons.library.tmc.edu/baylor_docs/8542