Language
English
Publication Date
1-22-2024
Journal
International Journal of Molecular Sciences
DOI
10.3390/ijms25021349
PMID
38279349
PMCID
PMC10816972
PubMedCentral® Posted Date
1-22-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Retinal ischemia plays a vital role in vision-threatening retinal ischemic disorders, such as diabetic retinopathy, age-related macular degeneration, glaucoma, etc. The aim of this study was to investigate the effects of S-allyl L-cysteine (SAC) and its associated therapeutic mechanism. Oxidative stress was induced by administration of 500 μM H2O2 for 24 h; SAC demonstrated a dose-dependent neuroprotective effect with significant cell viability effects at 100 μM, and it concurrently downregulated angiogenesis factor PKM2 and inflammatory biomarker MCP-1. In a Wistar rat model of high intraocular pressure (HIOP)-induced retinal ischemia and reperfusion (I/R), post-administration of 100 μM SAC counteracted the ischemic-associated reduction of ERG b-wave amplitude and fluorogold-labeled RGC reduction. This study supports that SAC could protect against retinal ischemia through its anti-oxidative, anti-angiogenic, anti-inflammatory, and neuroprotective properties.
Keywords
Rats, Animals, Rats, Wistar, Cysteine, Hydrogen Peroxide, Reperfusion Injury, Retinal Diseases, Ischemia, Neuroprotective Agents, Anti-Inflammatory Agents, Glaucoma, S-allyl L-cysteine, retinal pigment epithelium, retinal ganglion cell, pyruvate kinase M2, monocyte chemoattractant protein-1, hydrogen peroxide, oxidative stress, retinal ischemia
Published Open-Access
yes
Recommended Citation
Chao, Windsor Wen-Jin; Chao, Howard Wen-Haur; Lee, Hung-Fu; et al., "The Effect of S-Allyl L-Cysteine on Retinal Ischemia: The Contributions of MCP-1 and PKM2 in the Underlying Medicinal Properties" (2024). Faculty, Staff and Students Publications. 8546.
https://digitalcommons.library.tmc.edu/baylor_docs/8546