Language

English

Publication Date

9-8-2026

Journal

Biomedical Microdevices

DOI

10.1007/s10544-026-00836-8

PMID

42709284

PMCID

PMC13553663

PubMedCentral® Posted Date

9-8-2026

PubMedCentral® Full Text Version

Post-print

Abstract

Nanomedicine has progressed far beyond its early role as an experimental drug-carrier toolbox and today stands as a clinically validated enabling technology. Liposomal formulations and albumin-bound nanoparticles have transformed cancer therapy, while lipid nanoparticle (LNP) platforms accelerated the rapid development and global deployment of SARS-CoV-2 mRNA vaccines-demonstrating how nanoscale engineering can reshape therapeutic response, manufacturing speed, and public health impact. With these successes as foundation, the field is rapidly expanding into more sophisticated delivery systems including cell-hitchhiking nanoparticles, biomimetic multivalent vaccines, implantable immunotherapy depots, high-loading polymeric micelles, organ-targeted gene and RNA carriers, and bio-hybrid extracellular vesicle and mitochondrial therapies. These platforms aim not only to transport drugs, but to modulate immunity, direct regeneration, and enable precision intervention at the cellular and molecular scale. This perspective summarizes the current landscape of biomedical nanotechnologies and outlines how their continued evolution positions nanomedicine as an enabling science driving the next generation of therapeutics.

Keywords

Humans, Nanomedicine, Animals, Drug Carriers, Drug Delivery Systems, Immunotherapy, SARS-CoV-2, Nanoparticles, COVID-19

Published Open-Access

yes

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