Language
English
Publication Date
6-1-2025
Journal
Internal Medicine
DOI
10.2169/internalmedicine.4265-24
PMID
39496448
PMCID
PMC12222972
PubMedCentral® Posted Date
11-1-2024
PubMedCentral® Full Text Version
Post-print
Abstract
A 64-year-old Japanese woman presented with gross hematuria and was diagnosed with stage IVB cervical cancer. Renal dysfunction was observed following chemoradiation therapy, and a renal biopsy revealed renal thrombotic microangiopathy (TMA) and tubulointerstitial nephritis (TIN), which are atypical features of radiation nephropathy. Contrast-enhanced computed tomography revealed wedge-shaped areas of high contrast, consistent with areas of high radiation dose in the kidneys, thus leading to the diagnosis of radiation nephropathy. This case underscores the importance of integrating clinical, pathological, and radiological findings for the diagnosis of radiation nephropathy, atypical renal biopsy findings, and a combination of TIN and renal TMA.
Keywords
Humans, Nephritis, Interstitial, Female, Middle Aged, Radiation Injuries, Lymphocytes, Plasma Cells, Uterine Cervical Neoplasms, Thrombotic Microangiopathies, radiation nephropathy, thrombotic microangiopathy, tubulointerstitial nephritis, contrast-enhanced computed tomography
Published Open-Access
yes
Recommended Citation
Kosaka, Tatsuaki; Takaori, Koji; Izumiya, Azusa; et al., "Radiation Nephropathy Complicated by Tubulointerstitial Nephritis with Predominantly Lymphocyte and Plasma Cell Infiltration" (2025). Faculty, Staff and Students Publications. 8724.
https://digitalcommons.library.tmc.edu/baylor_docs/8724