Language

English

Publication Date

1-1-2025

Journal

Nephron

DOI

10.1159/000544709

PMID

39947166

PMCID

PMC12215155

PubMedCentral® Posted Date

2-13-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Glomerular diseases with organized deposits can be classified into various etiologies. A diagnostic algorithm based on clinical and pathological findings has been proposed. However, some cases cannot be diagnosed using existing algorithms. Here, we report the case of a 77-year-old man diagnosed with membranoproliferative glomerulonephritis (MPGN) with striated ultrastructural deposits, micro-filament-like substructures with straight bands arranged in parallel in the subendothelial space by two sequential renal biopsies. His examinations and clinical findings were incompatible with known glomerular diseases with organized deposits. Dialysis was initiated 10 months after the second biopsy procedure. Furthermore, we report the first mass spectrometry analysis of laser micro-dissected glomeruli with striated ultrastructural deposits, which revealed significant levels of fibrinogen and fibronectin. Immunostaining was positive for fibrinogen, fibrin, and fibronectin in the subendothelial space. These findings suggest that the deposits were composed of a fibrin-fibronectin complex and that accumulation of these fibrin-fibronectin complexes possibly induced endothelial injury, leading to MPGN. We also reviewed the literature on the clinical and pathological characteristics of the four cases with striated ultrastructural deposits. Our investigation showed that all patients had the MPGN pattern and striated ultrastructural deposits in the subendothelial space, and all underwent hemodialysis within 3 years of renal biopsy. Clinicians should be aware of the findings of glomerulonephritis with striated ultrastructural deposits since this disease may be a new entity and has a poor prognosis.

Keywords

Humans, Male, Glomerulonephritis, Membranoproliferative, Aged, Fibrinogen, Fibronectins, Mass Spectrometry, Kidney Glomerulus, Renal Dialysis, Membranoproliferative glomerulonephritis, Fibrinogen, Fibrin, Fibronectin, Deposit, Mass spectrometry

Published Open-Access

yes

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