Estimating the Accuracy and Additionality of TB-LAM to Diagnose TB in Children Without HIV (AccuLAM)

Authors

• Lucía Carratalà Castro
• Shilzia Munguambe
• Alexander Kay
• Willy Ssengooba
• Durbbin Mulengwa
• Sozinho Acácio
• Joanna Ehrlich
• Andrew R DiNardo
• Anca Vasiliu
• Abigail Seeger
• Edson Mambuque
• Clement Gascua Adu-Gyamfi
• Helton Timoteo
• Christoph Lange
• Sabine Hermans
• Anna Mandalakas
• Elisa López-Varela
• Alberto L García-Basteiro

Language

English

Publication Date

2-25-2026

Journal

Clinical Infectious Diseases

DOI

10.1093/cid/ciaf525

PMID

41208371

Abstract

New diagnostic tests and alternative samples to diagnose tuberculosis in children are needed to tackle the diagnostic gap of pediatric tuberculosis. The Determine TB LAM Ag test in urine demonstrated sensitivity of 15.9% and specificity of 90.6%. Collecting the urine in adhesive bag was an independent risk factor for positivity (odds ratio, 11.38; P < .01).

Keywords

contamination, false positives, pediatric tuberculosis, point-of-care diagnostics, urine

Published Open-Access

yes

Recommended Citation

Carratalà Castro, Lucía; Munguambe, Shilzia; Kay, Alexander; et al., "Estimating the Accuracy and Additionality of TB-LAM to Diagnose TB in Children Without HIV (AccuLAM)" (2026). Faculty, Staff and Students Publications. 8797.
https://digitalcommons.library.tmc.edu/baylor_docs/8797