Examining General Toxicity and Risk Factors for Toxicity in Persons Receiving Intensity-Modulated Radiation Therapy Versus 3-Dimensional Conformal Radiation Therapy for Esophageal Cancer
Esophageal cancer (EC) is one of the most aggressive malignancies. Three-dimensional conformal radiation therapy and intensity-modulated radiation therapy are common therapies of esophageal cancer; however, few publications have used population-based databases to explore the cause-specific survival and general toxicity for EC patients receiving different radiation modalities. To explore general toxicities and risk factors for toxicities, we used the MarketScan data collected from 2002 to 2015. Patients with available radiation information for 3D-CRT or IMRT were included. Logistic regression and inverse probability of treatment weights were performed to evaluate the differences of the two radiation modalities in general toxicities and risk factors for toxicities. Our study indicated that EC patients aged ≤65 years who used IMRT had fewer emergency department visits than similarly aged patients who used 3D-CRT. For elderly patients, no statistically significant differences were observed for cardiac- or pulmonary-relevant complications in patients using 3D-CRT compared to patients using IMRT.^
Deng, Weiye, "Examining General Toxicity and Risk Factors for Toxicity in Persons Receiving Intensity-Modulated Radiation Therapy Versus 3-Dimensional Conformal Radiation Therapy for Esophageal Cancer" (2017). Texas Medical Center Dissertations (via ProQuest). AAI10683205.