Optimal frequency of Imiquimod (Aldara(reg)) 5% cream treatment of external genital warts in immunocompetent adults. Systematic review and meta-analysis
Abstract
Genital warts are a sexually transmitted disease with high prevalence in the U.S. Imiquimod 5% cream is a self-applied treatment, prescribed three-times weekly, at bedtime, for 16 weeks. The post-marketing research addressed questions of imiquimod dosing frequency. MEDLINE, Embase, and the Cochrane Library were searched for randomized trials on efficacy and safety of imiquimod 5% cream with either three-times weekly or once-daily regimens to systemically review treatment options. Efficacy was evaluated by completely cleared warts at the end of treatment, and safety - by frequency of adverse events and at least one rest period taken from treatment. Six studies were selected for the analysis, including circumcised men, uncircumcised men, and women. The once-daily compared to three-times weekly regimen did not improve the efficacy, but resulted in increased incidence of local skin reactions and events, when at least one rest period was taken from treatment. The optimal regimen is three-times weekly.
Subject Area
Public health|Epidemiology
Recommended Citation
Gotovtseva, Elena P, "Optimal frequency of Imiquimod (Aldara(reg)) 5% cream treatment of external genital warts in immunocompetent adults. Systematic review and meta-analysis" (2007). Texas Medical Center Dissertations (via ProQuest). AAI1444055.
https://digitalcommons.library.tmc.edu/dissertations/AAI1444055