Molecular pathway activation in cancer and tissue following space radiation exposure

Tatiana A Kovyrshina, The University of Texas School of Public Health

Abstract

Space radiation exposure is an important safety concern for astronauts, especially since one of the risks is carcinogenesis. This thesis explores the link between lung, colorectal, and breast cancer and iron particles and gamma radiation on a molecular level. We obtained DNA microarrays for each condition from the Gene Expression Omnibus (GEO), a public functional genomics data repository, cleaned up the data, and analysed overexpression and underexpression of pathway analysis. Our results show that pathways which participate in DNA replication appear to be overexpressed in cancer cells and cells exposed to ionizing radiation.^

Subject Area

Biology, Bioinformatics|Physics, Radiation|Health Sciences, Oncology

Recommended Citation

Kovyrshina, Tatiana A, "Molecular pathway activation in cancer and tissue following space radiation exposure" (2014). Texas Medical Center Dissertations (via ProQuest). AAI1569938.
http://digitalcommons.library.tmc.edu/dissertations/AAI1569938

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