Ethanol-induced gastric damage in the rat: Lack of a correlation with oxygen-derived free radicals
Abstract
The present study investigated the role of oxygen-derived free radicals as mediators of acute damage to rat gastric mucosae exposed to topically applied absolute ethanol. Although a hydroxyl radical scavenger, Dimethylthiourea, was noted to exhibit profound gastroprotective properties, other pretreatment regimens employing a host of known free radical scavengers, and enzyme inhibitors failed to confirm this hypothesis. Furthermore, no change in mucosal malondialdehyde, an indicator of free radical attack to cell membranes, could be detected in ethanol exposed tissues. Taken together, the present study fails to confirm that oxygen-derived free radicals mediate the gastric damaging effects of topically applied absolute ethanol.
Subject Area
Anatomy & physiology|Animals|Cellular biology|Anatomy & physiology
Recommended Citation
Smith, Gregory Scott, "Ethanol-induced gastric damage in the rat: Lack of a correlation with oxygen-derived free radicals" (1993). Texas Medical Center Dissertations (via ProQuest). AAI9333702.
https://digitalcommons.library.tmc.edu/dissertations/AAI9333702