Lineage Tracing Reveals a Shared Cellular Origin for Supraclavicular Brown and Inguinal Beige Adipocytes

Authors

• Yali Ran
• Kai Zhang
• Yi-Ting Shen
• Qianxing Mo
• Ziyi Wang
• Hari Krishna Yalamanchili
• Sharon John
• Mari Kogiso
• Xia Gao
• Chunmei Wang
• Tanvi Sinha
• Brian L Black
• Miao-Hsueh Chen

Language

English

Publication Date

8-14-2026

Journal

Cell Reports

DOI

10.1016/j.celrep.2026.117836

PMID

42599804

Abstract

The metabolic importance of brown adipose tissue (BAT) has been recognized, but its origins, particularly supraclavicular BAT (scBAT), remain unclear. Here, we traced scBAT to Mef2c-anterior heart field (AHF)-marked cells. Mef2c-AHF-marked cells isolated from scBAT can spontaneously differentiate into brown adipocytes, express mesenchymal stem cell markers, and can be isolated from the stromal-vascular fraction (SVF) of wild-type scBAT as [CD31

Keywords

CP: developmental biology, CP: metabolism, beige adipocytes, lineage tracing, scBAT, supraclavicular brown adipose tissue

Published Open-Access

yes

Recommended Citation

Ran, Yali; Zhang, Kai; Shen, Yi-Ting; et al., "Lineage Tracing Reveals a Shared Cellular Origin for Supraclavicular Brown and Inguinal Beige Adipocytes" (2026). Duncan NRI Faculty and Staff Publications. 254.
https://digitalcommons.library.tmc.edu/duncar_nri_pub/254