Publication Date
10-1-2017
Journal
The Texas Heart Journal
DOI
10.14503/THIJ-15-5338
PMID
29259499
Publication Date(s)
October 2017
Language
English
PMCID
PMC5731582
PubMedCentral® Posted Date
10-1-2017
PubMedCentral® Full Text Version
Post-Print
Published Open-Access
yes
Keywords
Biomarkers/analysis/blood, coronary disease/diagnosis, myocardial ischemia/pathology, predictive value of tests, prospective studies, tachycardia, paroxysmal/blood/diagnosis, tachycardia, supraventricular/blood/diagnosis, time factors, troponin T/analysis/blood
Copyright
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Abstract
We studied the predictors and patterns of high-sensitivity cardiac troponin T (hs-cTnT) elevation in patients with paroxysmal supraventricular tachycardia (PSVT) in the presence and absence of ischemic heart disease.
During calendar year 2013, we enrolled 70 of 72 consecutive adult patients with PSVT who presented at our center within 4 hours after the onset of tachycardia. On the basis of increased hs-cTnT at either of 2 initial measurements, we divided patients into groups (hs-cTnT–positive and hs-cTnT–negative), to study the predictors of enzyme elevation. We then divided the hs-cTnT–positive patients into 2 groups—those with and those without ischemic heart disease—and compared hs-cTnT changes.
We observed hs-cTnT elevation in 52 of the 70 patients (74.3%). The hs-cTnT–positive patients were significantly older (P=0.008) and had a significantly higher duration of tachycardia (P=0.01). Older age, the presence of chest pain, lower diastolic blood pressure, and longer duration of tachycardia increased the odds of enzyme elevation. Among patients with elevated hs-cTnT levels, the baseline and maximal hs-cTnT levels were significantly higher in ischemic patients (P=0.01 and P=0.003, respectively). The increase in hs-cTnT seemed to be higher and longer in ischemic patients, although this was not statistically significant (P=0.908). Finally, hs-cTnT did not decrease to baseline levels within 48 hours in either group.
We found that hs-cTnT levels increased in all our patients with PSVT, more so in those with ischemic heart disease.