Publication Date
2013
Journal
The Texas Heart Journal
PMID
23914009
Publication Date(s)
2013
Language
English
PMCID
PMC3709209
PubMedCentral® Posted Date
2013
PubMedCentral® Full Text Version
Post-Print
Published Open-Access
yes
Keywords
Apoptosis, autophagy, cardioprotection, inflammation mediators, ischemic preconditioning, myocardial, myocardial ischemia/physiopathology, myocardial reperfusion injury/physiopathology, myocardial stunning/physiopathology, myocytes, cardiac/pathology, mitochondria, myocardial reperfusion injury, myocardium/cytology/ultrastructure, myocytes, cardiac/pathology, necrosis/prevention & control, oncosis, regeneration/physiology, reperfusion injury, signal transduction, stem cell transplantation
Copyright
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Abstract
Ongoing investigation has provided new insights into the pathobiology of myocardial ischemic injury. These include an improved understanding of the roles of the major modes of cell injury and death, including oncosis, apoptosis, and unregulated autophagy, as well as the central role of the mitochondria in the progression of myocardial ischemic injury, reperfusion injury, and myocardial conditioning. This understanding is providing insights for developing new pathophysiologic, pharmacologic, and cell-based therapies, alone or in combination with percutaneous coronary interventions, for better preservation of myocardium and reduction of morbidity and mortality rates from ischemic heart disease.