Publication Date
6-1-2020
Journal
The Texas Heart Institute Journal
DOI
10.14503/THIJ-18-6849
PMID
32997783
Publication Date(s)
June 2020
Language
English
PMCID
PMC7529072
PubMedCentral® Posted Date
9-30-2020
PubMedCentral® Full Text Version
Post Print
Published Open-Access
yes
Keywords
Aged, Amiodarone, Anti-Arrhythmia Agents, Atrial Fibrillation, Female, Follow-Up Studies, Humans, Hyponatremia, Intelligence Tests, Mental Health, Time Factors
Copyright
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Abstract
A 66-year-old woman with no relevant medical history presented at the emergency department with new-onset atrial fibrillation. We initiated intravenous amiodarone therapy. At 20 hours, the patient experienced severe neurologic symptoms, hyponatremia, and syndrome of inappropriate antidiuretic hormone. We discontinued amiodarone, infused saline solution, and restricted the patient's fluid intake. She recovered in 3 days. This case illustrates that amiodarone-induced syndrome of inappropriate antidiuretic hormone with hyponatremia can occur far earlier than expected during acute amiodarone therapy.