Publication Date

6-1-2020

Journal

The Texas Heart Institute Journal

DOI

10.14503/THIJ-18-6849

PMID

32997783

Publication Date(s)

June 2020

Language

English

PMCID

PMC7529072

PubMedCentral® Posted Date

9-30-2020

PubMedCentral® Full Text Version

Post-Print

Published Open-Access

yes

Keywords

Aged, Amiodarone, Anti-Arrhythmia Agents, Atrial Fibrillation, Female, Follow-Up Studies, Humans, Hyponatremia, Intelligence Tests, Mental Health, Time Factors

Abstract

A 66-year-old woman with no relevant medical history presented at the emergency department with new-onset atrial fibrillation. We initiated intravenous amiodarone therapy. At 20 hours, the patient experienced severe neurologic symptoms, hyponatremia, and syndrome of inappropriate antidiuretic hormone. We discontinued amiodarone, infused saline solution, and restricted the patient's fluid intake. She recovered in 3 days. This case illustrates that amiodarone-induced syndrome of inappropriate antidiuretic hormone with hyponatremia can occur far earlier than expected during acute amiodarone therapy.

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