Publication Date
7-1-2021
Journal
The Texas Heart Institute Journal
DOI
10.14503/THIJ-20-7243
PMID
34383956
Publication Date(s)
July 2021
Language
English
PMCID
PMC8367288
PubMedCentral® Posted Date
8-12-2021
PubMedCentral® Full Text Version
Post Print
Published Open-Access
yes
Keywords
Cardiovascular diseases, cohort studies, heart failure, inpatients/statistics & numerical data, mitochondrial diseases, propensity score
Copyright
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Abstract
Mitochondrial disease comprises a wide range of genetic disorders caused by mitochondrial dysfunction. Its rarity, however, has limited the ability to assess its effects on clinical outcomes. To evaluate this relationship, we collected data from the 2016 National Inpatient Sample, which includes data from >7 million hospital stays. We identified 705 patients (mean age, 22 ± 20.7 yr; 54.2% female; 67.4% white) whose records included the ICD-10-CM code E88.4. We also identified a propensity-matched cohort of 705 patients without mitochondrial disease to examine the effect of mitochondrial disease on major adverse cardiovascular events, including all-cause in-hospital death, cardiac arrest, and acute congestive heart failure.
Patients with mitochondrial disease were at significantly greater risk of major adverse cardiovascular events (odds ratio [OR]=2.42; 95% CI, 1.29–4.57; P=0.005), systolic heart failure (OR=2.37; 95% CI, 1.08–5.22; P=0.027), and all-cause in-hospital death (OR=14.22; 95% CI, 1.87–108.45; P<0.001).
These findings suggest that mitochondrial disease significantly increases the risk of inpatient major adverse cardiovascular events.