Fundamental of Secondary Structures in Peptide Based Synthetic Nanovaccine Development

Rajagopal Appavu, MD Anderson Cancer Center, Houston, TX
Deepa Mohan, Indian Institute of Sciences, Bangalore, India
Ramu Kakumanu, The University of Texas Medical Branch, Galveston, TX
Govindaraju Munisamy, Bharathidasan University, Tamil Nadu, India


The peptides vaccines composed of the twenty genetically coded amino acids generally exist as an ensemble of different conformational states in solution. The induction of folded conformations in short peptide vaccine sequences may be achieved by the incorporation of stereochemically constrained non-coded amino acids. This review briefly provides a basic understanding of this method of vaccine development.