Date of Graduation

5-2016

Document Type

Dissertation (PhD)

Program Affiliation

Cancer Biology

Degree Name

Doctor of Philosophy (PhD)

Advisor/Committee Chair

Mien-Chie Hung

Committee Member

Dihua Yu

Committee Member

Ann-Bin Shyu

Committee Member

Dos D. Sarbassov

Committee Member

Li Ma

Abstract

The Yes-associated protein (YAP) is an effector that transduces the output of the Hippo pathway to transcriptional modulation. Considering the role of YAP in cancers, this protein has emerged as a key node in malignancy development. In this study, we determined that Aurora A kinase acts as a positive regulator for YAP-mediated transcriptional machinery. Specifically, YAP associates with Aurora A predominantly in the nucleus. Activation of Aurora A can impinge on YAP activity through direct phosphorylation. Moreover, aberrant expression of YAP and Aurora A signaling is highly correlated with triple-negative breast cancer (TNBC). We herein provide evidence to establish the functional relevance of this newly discovered regulatory axis in TNBC. This study not only has advanced the understanding of the intricate network of YAP in cancers but also has revealed a potential route to intervene oncogenic YAP function.

Keywords

YAP, Aurora, Phosphorylation, Transcription, Breast Cancer

Available for download on Tuesday, April 25, 2017

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