Open-access journal articles from UT GSBS faculty and students.

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Submissions from 2010

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S9511: a Southwest Oncology Group phase II study of trimetrexate, 5-fluorouracil, and leucovorin in unresectable or metastatic adenocarcinoma of the stomach., Charles D Blanke, Kari Chansky, Kathy L Christman, Scott A Hundahl, Brian F Issell, Peter J Van Veldhuizen, G Thomas Budd, James L Abbruzzese, and John S Macdonald

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FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes., Bingbing Dai, Russell O Pieper, Dawei Li, Ping Wei, Mingguang Liu, Shiao Y Woo, Kenneth D Aldape, Raymond Sawaya, Keping Xie, and Suyun Huang

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Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activity., Kei-ichi Takata, Mercedes E Arana, Mineaki Seki, Thomas A Kunkel, and Richard D Wood

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Loss of DNA polymerase zeta enhances spontaneous tumorigenesis., John P Wittschieben, Vaishali Patil, Veronika Glushets, Lisa J Robinson, Donna F Kusewitt, and Richard D Wood

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Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer., Zhengdong Zhang, Luo Wang, Sheng Wei, Zhensheng Liu, Li-E Wang, Erich M Sturgis, and Qingyi Wei

Submissions from 2009

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CA125/MUC16 is dispensable for mouse development and reproduction., Dong-Joo Cheon, Ying Wang, Jian Min Deng, Zhen Lu, Lianchun Xiao, Chun-Ming Chen, Robert C Bast, and Richard R Behringer

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CREB mediates prostaglandin F2alpha-induced MUC5AC overexpression., Wen-Cheng Chung, Seung-Hee Ryu, Hongxia Sun, Darryl C Zeldin, and Ja Seok Koo

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Dicer is required for female reproductive tract development and fertility in the mouse., Gabriel Gonzalez and Richard R Behringer

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Long-term survival after multidisciplinary management of resected pancreatic adenocarcinoma., Matthew H G Katz, Huamin Wang, Jason B Fleming, Charlotte C Sun, Rosa F Hwang, Robert A Wolff, Gauri Varadhachary, James L Abbruzzese, Christopher H Crane, Sunil Krishnan, Jean-Nicolas Vauthey, Eddie K Abdalla, Jeffrey E Lee, Peter W T Pisters, and Douglas B Evans

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KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta., Dung-Fang Lee, Hsu-Ping Kuo, Mo Liu, Chao-Kai Chou, Weiya Xia, Yi Du, Jia Shen, Chun-Te Chen, Longfei Huo, Ming-Chuan Hsu, Chia-Wei Li, Qingqing Ding, Tsai-Lien Liao, Chien-Chen Lai, Ann-Chi Lin, Ya-Hui Chang, Shih-Feng Tsai, Long-Yuan Li, and Mien-Chie Hung

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Therapeutic Targeting of ATP7B in Ovarian Carcinoma., Lingegowda S Mangala, Vesna Zuzel, Rosemarie Schmandt, Erik S Leshane, Jyotsna B Halder, Guillermo N Armaiz-Pena, Whitney A Spannuth, Takemi Tanaka, Mian M K Shahzad, Yvonne G Lin, Alpa M Nick, Christopher G Danes, Jeong-Won Lee, Nicholas B Jennings, Pablo E Vivas-Mejia, Judith K Wolf, Robert L Coleman, Zahid H Siddik, Gabriel Lopez-Berestein, Svetlana Lutsenko, and Anil K Sood

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Antibodies targeting hepatoma-derived growth factor as a novel strategy in treating lung cancer., Hening Ren, Zuoming Chu, and Li Mao

Submissions from 2008

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An Sp1/Sp3 binding polymorphism confers methylation protection., Yanis A. Boumber, Yutaka Kondo, Xuqi Chen, Lanlan Shen, Yi Guo, Carmen Tellez, Marcos R H Estécio, Saira Ahmed, and Jean-Pierre J. Issa

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Killing of human melanoma cells induced by activation of class I interferon-regulated signaling pathways via MDA-7/IL-24., Suhendan Ekmekcioglu, John B Mumm, Malini Udtha, Sunil Chada, and Elizabeth A Grimm

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Sp1 up-regulates cAMP-response-element-binding protein expression during retinoic acid-induced mucous differentiation of normal human bronchial epithelial cells., Jeong Soo Hong, Seung-Wook Kim, and Ja Seok Koo

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Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse., Chai-An Mao, Takae Kiyama, Ping Pan, Yasuhide Furuta, Anna-Katerina Hadjantonakis, and William H Klein

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LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis., Davide Melisi, Satoshi Ishiyama, Guido M Sclabas, Jason B Fleming, Qianghua Xia, Giampaolo Tortora, James L Abbruzzese, and Paul J Chiao

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Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome., Mala Pande, Christopher I Amos, Daniel R Osterwisch, Jinyun Chen, Patrick M Lynch, Russell Broaddus, and Marsha L Frazier

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REST maintains self-renewal and pluripotency of embryonic stem cells., Sanjay K Singh, Mohamedi N Kagalwala, Jan Parker-Thornburg, Henry Adams, and Sadhan Majumder

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FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells., Yujian Zhang, Nu Zhang, Bingbing Dai, Mingguang Liu, Raymond Sawaya, Keping Xie, and Suyun Huang

Submissions from 2007

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Phosphorylation of the proline-rich domain of Xp95 modulates Xp95 interaction with partner proteins., Robert E Dejournett, Ryuji Kobayashi, Shujuan Pan, Chuanfen Wu, Laurence D Etkin, Richard B Clark, Oliver Bögler, and Jian Kuang

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Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia., Benjamin T Kile, Athanasia D Panopoulos, Roslynn A Stirzaker, Douglas F Hacking, Lubna H Tahtamouni, Tracy A Willson, Lisa A Mielke, Katya J Henley, Jian-Guo Zhang, Ian P Wicks, William S Stevenson, Paquita Nurden, Stephanie S Watowich, and Monica J Justice

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Regulation of mucin gene expression by CREB via a nonclassical retinoic acid signaling pathway., Seung-Wook Kim, Jeong Soo Hong, Seung-Hee Ryu, Wen-Cheng Chung, Joo-Heon Yoon, and Ja Seok Koo

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Is a 3-mm intrafractional margin sufficient for daily image-guided intensity-modulated radiation therapy of prostate cancer?, Adam D Melancon, Jennifer C O'Daniel, Lifei Zhang, Rajat J Kudchadker, Deborah A Kuban, Andrew K Lee, Rex M Cheung, Renaud de Crevoisier, Susan L Tucker, Wayne D Newhauser, Radhe Mohan, and Lei Dong

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K1 protein of human herpesvirus 8 suppresses lymphoma cell Fas-mediated apoptosis., Suizhao Wang, Shu Wang, Hoyoung Maeng, Daniel P Young, Om Prakash, Luis E Fayad, Anas Younes, and Felipe Samaniego

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Single-stranded DNA-binding proteins regulate the abundance of LIM domain and LIM domain-binding proteins., Zhixiong Xu, Xianzhang Meng, Ying Cai, Hong Liang, Lalitha Nagarajan, and Stephen J Brandt

Submissions from 2006

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Constitutive NF-kappaB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas., Lingchen Fu, Yen-Chiu Lin-Lee, Lan V Pham, Archito Tamayo, Linda Yoshimura, and Richard J Ford

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Natriuretic peptides and nitric oxide stimulate cGMP synthesis in different cellular compartments., Leslie A Piggott, Kathryn A Hassell, Zuzana Berkova, Andrew P Morris, Michael Silberbach, and Thomas C Rich

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Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation., Xiaohua Su, Vidya Gopalakrishnan, Duncan Stearns, Kenneth Aldape, Fredrick F Lang, Gregory Fuller, Evan Snyder, Charles G Eberhart, and Sadhan Majumder

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Platelet-activating factor is crucial in psoralen and ultraviolet A-induced immune suppression, inflammation, and apoptosis., Peter Wolf, Dat X Nghiem, Jeffrey P Walterscheid, Scott Byrne, Yumi Matsumura, Yasuhiro Matsumura, Cora Bucana, Honnavara N Ananthaswamy, and Stephen E Ullrich

Submissions from 2005

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Activation of Src kinase Lyn by the Kaposi sarcoma-associated herpesvirus K1 protein: implications for lymphomagenesis., Om Prakash, O Rama Swamy, Xiochang Peng, Zhen-Ya Tang, Li Li, Janet E Larson, J Craig Cohen, Javed Gill, Gist Farr, Suizhao Wang, and Felipe Samaniego

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Prime-boost vaccination with plasmid and adenovirus gene vaccines control HER2/neu+ metastatic breast cancer in mice., Xiaoyan Wang, Jian-Ping Wang, Xiao-Mei Rao, Janet E Price, Heshan S Zhou, and Lawrence B Lachman

Submissions from 2004

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NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity., Shuichi Fujioka, Jiangong Niu, Christian Schmidt, Guido M Sclabas, Bailu Peng, Tadashi Uwagawa, Zhongkui Li, Douglas B Evans, James L Abbruzzese, and Paul J Chiao

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Conversion of myoblasts to physiologically active neuronal phenotype., Yumi Watanabe, Sei Kameoka, Vidya Gopalakrishnan, Kenneth D Aldape, Zhizhong Z Pan, Frederick F Lang, and Sadhan Majumder

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The recombinant adeno-associated virus vector (rAAV2)-mediated apolipoprotein B mRNA-specific hammerhead ribozyme: a self-complementary AAV2 vector improves the gene expression., Shumei Zhong, Shihua Sun, and Ba-Bie Teng

Submissions from 2003

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rIFN-gamma-mediated growth suppression of platinum-sensitive and -resistant ovarian tumor cell lines not dependent upon arginase inhibition., Bohuslav Melichar, Wei Hu, Rebecca Patenia, Karolina Melicharová, Stacie T Gallardo, and Ralph Freedman

Submissions from 1993

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Estimation of the incidence of a rare genetic disease through a two-tier mutation survey., R Chakraborty, M R Srinivasan, and S Raskin

Submissions from 1992

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Multiple alleles and estimation of genetic parameters: computational equations showing involvement of all alleles., R Chakraborty

Submissions from 1991

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Inclusion of data on relatives for estimation of allele frequencies., R Chakraborty

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Statistical interpretation of DNA typing data., R Chakraborty

Submissions from 1988

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Parentage analysis with genetic markers in natural populations. I. The expected proportion of offspring with unambiguous paternity., R Chakraborty, T R Meagher, and P E Smouse

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Population amalgamation and genetic variation: observations on artificially agglomerated tribal populations of Central and South America., R Chakraborty, P E Smouse, and J V Neel

Submissions from 1984

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Detection of nonrandom association of alleles from the distribution of the number of heterozygous loci in a sample., R Chakraborty

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Genetics and epidemiology of gallbladder disease in New World native peoples., K M Weiss, R E Ferrell, C L Hanis, and P N Styne

Submissions from 1982

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Genetically controlled variation of "acid" beta-galactosidase detected in Rattus norvegicus by isoelectric focusing., T C Douglas, K A Kimmel, and P E Dawson

Submissions from 1979

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Polymorphisms, linkage and mapping of four enzyme loci in the fish genus Xiphophorus (Poeciliidae)., D C Morizot and M J Siciliano

Submissions from 1977

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Three linked enzyme loci in fishes: implications in the evolution of vertebrate chromosomes., D C Morizot, D A Wright, and M J Siciliano