Evaluation of the Clinical and Radiographic Effectiveness of Treating Peri-Implant Bone Defects With a New Biphasic Calcium Phosphate Bone Graft: A Prospective, Multicenter Randomized Controlled Trial

Authors

Jae-Hong Lee
Hyun-Wook An
Jae-Seung Im
Woo-Joo Kim
Dong-Won Lee
Jeong-Ho Yun

Publication Date

8-1-2023

Journal

Journal of Periodontal & Implant Science

Abstract

PURPOSE: Biphasic calcium phosphate (BCP), a widely used biomaterial for bone regeneration, contains synthetic hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), the ratio of which can be adjusted to modulate the rate of degradation. The aim of this study was to evaluate the clinical and radiographic benefits of reconstructing peri-implant bone defects with a newly developed BCP consisting of 40% β-TCP and 60% HA compared to demineralized bovine bone mineral (DBBM).

METHODS: This prospective, multicenter, parallel, single-blind randomized controlled trial was conducted at the periodontology departments of 3 different dental hospitals. Changes in clinical (defect width and height) and radiographic (augmented horizontal bone thickness) parameters were measured between implant surgery with guided bone regeneration (GBR) and re-entry surgery. Postoperative discomfort (severity and duration of pain and swelling) and early soft-tissue wound healing (dehiscence and inflammation) were also assessed. Data were compared between the BCP (test) and DBBM (control) groups using the independent

RESULTS: Of the 53 cases included, 27 were in the test group and 26 were in the control group. After a healing period of 18 weeks, the full and mean resolution of buccal dehiscence defects were 59.3% (n=16) and 71.3% in the test group and 42.3% (n=11) and 57.9% in the control group, respectively. There were no significant differences between the groups in terms of the change in mean horizontal bone augmentation (test group: -0.50±0.66 mm vs. control groups: -0.66±0.83 mm,

CONCLUSION: The GBR procedure with the newly developed BCP showed favorable clinical, radiographic, postoperative discomfort-related, and early wound healing outcomes for peri-implant dehiscence defects that were similar to those for DBBM.

Keywords

Allografts, Bone regeneration, Bone substitutes, Dental implants, Randomized controlled trial

Comments

This article has been corrected. See J Periodontal Implant Sci. 2024 June; 54(3): 205.

Clinical Research Information Service Identifier: KCT0006428

PMID: 37524378