An International Phantom Study of Inter-Site Variability in Technetium-99m Image Quantification: Analyses From the Target Radioembolization Study

Authors

Grace Keane
Rob van Rooij
Marnix Lam
S Cheenu Kappadath
Bilal Kovan
Stephanie Leon
Matthew Dreher
Kirk Fowers
Hugo de Jong

Publication Date

5-29-2024

Journal

EJNMMI Physics

Abstract

BACKGROUND: Personalised multi-compartment dosimetry based on [

RESULTS: Regarding the LSF, inter-site variation with planar site-specific protocols was minimal, as determined by comparing computed LSF between sites (interquartile range 9.6-10.1%). A standardised protocol did not improve variation (interquartile range 8.4-9.0%) but did improve mean accuracy compared to the site-specific protocols (5.0% error for standardised protocol vs 8.8% error for site-specific protocols). Regarding the CRC, inter-system variation was notable for site-specific SPECT protocols and could not be improved by the standardised protocol (CRC interquartile range for 37 mm sphere 0.5-0.7 and 0.6-0.8 respectively), however the standardised protocol did improve accuracy of sphere:background determination. Implementation of key image corrections did improve inter-site variation (CRC interquartile range for 37 mm sphere 0.6-0.7).

CONCLUSION: Eliminating sources of variability in image corrections between imaging protocols reduces inter-site variation in quantification. A standardised protocol was not able to improve consistency of LSF or CRC but was able to improve accuracy.

Keywords

Technetium-99m, Macroaggregated-albumin (MAA), Imaging, Performance, SPECT/CT, Harmonization, Yttrium-90

Comments

Supplementary Materials

PMID: 38809320