Juvenile onset central nervous system folate deficiency and rheumatoid arthritis.

Publication Date



J Child Neurol. 2008 January; 23(1): 106–107.


Isolated cerebral folate deficiency was detected in a 13-year-old girl with cognitive and motor difficulties and juvenile rheumatoid arthritis. Her serum contains autoantibodies that block membrane-bound folate receptors that are on the choroid plexus and diminish the uptake of folate into the spinal fluid. Whereas her serum folate exceeded 21 ng/mL, her spinal fluid contained 3.2 ng/mL of 5-methyltetrahydrofolate as a consequence of the autoantibodies diminishing the uptake of this folate.


Adolescent, Affective Symptoms, Age of Onset, Arthritis, Juvenile Rheumatoid, Autoantibodies, Brain, Brain Diseases, Metabolic, Carrier Proteins, Choroid Plexus, Cognition Disorders, Female, Folate Receptors, GPI-Anchored, Folic Acid, Folic Acid Deficiency, Humans, Magnetic Resonance Imaging, Motor Skills Disorders, Receptors, Cell Surface, Spinal Cord, Tetrahydrofolates