Activity of anidulafungin in a murine model of Candida krusei infection: evaluation of mortality and disease burden by quantitative tissue cultures and measurement of serum (1,3)-beta-D-glucan levels
Publication Date
4-1-2009
Journal
Antimicrob Agents Chemother. 2009 April; 53(4): 1639–1641.
Abstract
Experience with anidulafungin against Candida krusei is limited. Immunosuppressed mice were injected with 1.3 x 10(7) to 1.5 x 10(7) CFU of C. krusei. Animals were treated with saline, 40 mg/kg fluconazole, 1 mg/kg amphotericin B, or 10 and 20 mg/kg anidulafungin for 5 days. Anidulafungin improved survival and significantly reduced the number of CFU/g in kidneys and serum beta-glucan levels.
Keywords
Animals, Antifungal Agents, Candida, Candidiasis, Disease Models, Animal, Echinocandins, Kidney, Male, Mice, beta-Glucans