Publication Date
8-1-2023
Journal
Influenza and Other Respiratory Viruses
Abstract
BACKGROUND: Pregnant women are at high risk of developing febrile illness during the flu season. Early identification of a viral or bacterial infection is crucial in the management of febrile pregnant patients. Neutrophil CD64 (nCD64) has been shown to have more important diagnostic value in sepsis than traditional inflammatory indicators.
METHODS: The pregnant women enrolled were divided into three groups according to disease: influenza A infection, bacterial infection and healthy controls. Peripheral blood CD64, leukocyte, C-reactive protein (CRP), procalcitonin (PCT) and human Th1/Th2-related cytokines levels were routinely measured. The correlation between and diagnostic value of the nCD64 index and other biomarkers were evaluated using Spearman's correlation test and receiver operating characteristic (ROC) curve analysis.
RESULTS: Pregnant women with bacterial infection had significantly elevated levels of leukocytes (8.4 vs. 5.95, 10
CONCLUSIONS: Our study demonstrates the clinical value of the nCD64 index in distinguishing between bacterial infection and influenza A in pregnant women.
Keywords
Pregnancy, Humans, Female, Pregnant Women, Influenza, Human, Neutrophils, Seasons, Biomarkers, Bacterial Infections, C-Reactive Protein, Early Diagnosis, Procalcitonin