Publication Date
7-1-2022
Journal
International Journal of Molecular Sciences
Abstract
Combining aminoglycosides and loop diuretics often serves as an effective ototoxic approach to deafen experimental animals. The treatment results in rapid hair cell loss with extended macrophage presence in the cochlea, creating a sterile inflammatory environment. Although the early recruitment of macrophages is typically neuroprotective, the delay in the resolution of macrophage activity can be a complication if the damaged cochlea is used as a model to study subsequent therapeutic strategies. Here, we applied a high dose combination of systemic gentamicin and furosemide in
Keywords
Animals, Cochlea, Furosemide, Gentamicins, Hair Cells, Auditory, Outer, Macrophages, Mice, Mice, Inbred C57BL, Mice, Inbred CBA