Publication Date
1-1-2022
Journal
Frontiers in Molecular Biosciences
Abstract
NaPi2b is a sodium-dependent phosphate transporter that belongs to the SLC34 family of transporters which is mainly responsible for phosphate homeostasis in humans. Although NaPi2b is widely expressed in normal tissues, its overexpression has been demonstrated in ovarian, lung, and other cancers. A valuable set of antibodies, including L2 (20/3) and MX35, and its humanized versions react strongly with an antigen on the surface of ovarian and other carcinoma cells. Although the topology of NaPi2b was predicted
Keywords
SLC34A2, NaPi2b, MX35 antigen, topology, ECD, monoclonal antibody, ovarian cancer
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