Title

High Resolution Vascular Imaging of the Rat Spine using Liposomal Blood Pool MR Agent

Publication Date

2007

Journal

AJNR Am J Neuroradiol. 2007 January; 28(1): 48–53

Abstract

High resolution, vascular magnetic resonance imaging of the spine region in small animals poses several challenges. The small anatomical features, extravascular diffusion, and the low signal-to-noise ratio limit the use of conventional contrast agents. We hypothesize that a long circulating, intravascular liposomal-encapsulated MR contrast agent (liposomal-Gd) would facilitate visualization of small anatomical features of the perispinal vasculature not visible with conventional contrast agent (Gd-DTPA).

Keywords

Contrast Media/administration and dosage, Gadolinium DTPA/administration and dosage, image Enhancement/methods, Magnetic Resonance Angiography/methods, Spine/blood supply

Comments

PMCID: PMC1773015