Advanced Nano-Drug Delivery Systems In The Treatment of Ischemic Stroke

Authors

Language

English

Publication Date

4-18-2024

Journal

Molecules

DOI

10.3390/molecules29081848

PMID

38675668

PMCID

PMC11054753

PubMedCentral® Posted Date

April 2024

PubMedCentral® Full Text Version

Post-print

Abstract

In recent years, the frequency of strokes has been on the rise year by year and has become the second leading cause of death around the world, which is characterized by a high mortality rate, high recurrence rate, and high disability rate. Ischemic strokes account for a large percentage of strokes. A reperfusion injury in ischemic strokes is a complex cascade of oxidative stress, neuroinflammation, immune infiltration, and mitochondrial damage. Conventional treatments are ineffective, and the presence of the blood-brain barrier (BBB) leads to inefficient drug delivery utilization, so researchers are turning their attention to nano-drug delivery systems. Functionalized nano-drug delivery systems have been widely studied and applied to the study of cerebral ischemic diseases due to their favorable biocompatibility, high efficiency, strong specificity, and specific targeting ability. In this paper, we briefly describe the pathological process of reperfusion injuries in strokes and focus on the therapeutic research progress of nano-drug delivery systems in ischemic strokes, aiming to provide certain references to understand the progress of research on nano-drug delivery systems (NDDSs).

Keywords

Humans, Ischemic Stroke, Animals, Blood-Brain Barrier, Drug Delivery Systems, Reperfusion Injury, Nanoparticle Drug Delivery System, Nanoparticles, Brain Ischemia, ischemic stroke, nano-drug delivery system

Published Open-Access

yes

Recommended Citation

, "Advanced Nano-Drug Delivery Systems In The Treatment of Ischemic Stroke" (2024). Faculty, Staff and Student Publications. 366.
https://digitalcommons.library.tmc.edu/uthshis_docs/366