Chromosome 10Q2432 Variants associate With Brain arterial Diameters in Diverse Populations: a Genome-Wide association Study

Authors

Minghua Liu
Farid Khasiyev
Sanjeev Sariya
Antonio Spagnolo-Allende
Danurys L Sanchez
Howard Andrews
Qiong Yang
Alexa Beiser
Ye Qiao
Emy A Thomas
Jose Rafael Romero
Tatjana Rundek
Adam M Brickman
Jennifer J Manly
Mitchell Sv Elkind
Sudha Seshadri
Christopher Chen
Saima Hilal
Bruce A Wasserman
Giuseppe Tosto
Myriam Fornage
Jose Gutierrez

Publication Date

12-5-2023

Journal

Journal of the American Heart Association

Abstract

BACKGROUND: Brain arterial diameters (BADs) are novel imaging biomarkers of cerebrovascular disease, cognitive decline, and dementia. Traditional vascular risk factors have been associated with BADs, but whether there may be genetic determinants of BADs is unknown.

METHODS AND RESULTS: The authors studied 4150 participants from 6 geographically diverse population-based cohorts (40% European, 14% African, 22% Hispanic, 24% Asian ancestries). Brain arterial diameters for 13 segments were measured and averaged to obtain a global measure of BADs as well as the posterior and anterior circulations. A genome-wide association study revealed 14 variants at one locus associated with global BAD at genome-wide significance (

CONCLUSIONS: The current study reveals 3 novel risk loci (

Keywords

Humans, Brain, Genetic Predisposition to Disease, Genome-Wide Association Study, Methyltransferases, Polymorphism, Single Nucleotide, Chromosomes, Human, Pair 10