Association Between Whole Blood-Derived Mitochondrial Dna Copy Number, Low-Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk

Authors

Xue Liu
Xianbang Sun
Yuankai Zhang
Wenqing Jiang
Meng Lai
Kerri L Wiggins
Laura M Raffield
Lawrence F Bielak
Wei Zhao
Achilleas Pitsillides
Jeffrey Haessler
Yinan Zheng
Thomas W Blackwell
Jie Yao
Xiuqing Guo
Yong Qian
Bharat Thyagarajan
Nathan Pankratz
Stephen S Rich
Kent D Taylor
Patricia A Peyser
Susan R Heckbert
Sudha Seshadri
Eric Boerwinkle
Megan L Grove
Nicholas B Larson
Jennifer A Smith
Ramachandran S Vasan
Annette L Fitzpatrick
Myriam Fornage
Jun Ding
April P Carson
Goncalo Abecasis
Josée Dupuis
Alexander Reiner
Charles Kooperberg
Lifang Hou
Bruce M Psaty
James G Wilson
Daniel Levy
Jerome I Rotter
Joshua C Bis
Claudia L Satizabal
Dan E Arking
Chunyu Liu

Publication Date

10-17-2023

Journal

Journal of the American Heart Association

Abstract

Background The relationship between mitochondrial DNA copy number (mtDNA CN) and cardiovascular disease remains elusive. Methods and Results We performed cross-sectional and prospective association analyses of blood-derived mtDNA CN and cardiovascular disease outcomes in 27 316 participants in 8 cohorts of multiple racial and ethnic groups with whole-genome sequencing. We also performed Mendelian randomization to explore causal relationships of mtDNA CN with coronary heart disease (CHD) and cardiometabolic risk factors (obesity, diabetes, hypertension, and hyperlipidemia).

Keywords

Humans, DNA, Mitochondrial, Risk Factors, Cardiovascular Diseases, Cholesterol, LDL, DNA Copy Number Variations, Cross-Sectional Studies, Coronary Disease, Cholesterol, HDL, Diabetes Mellitus, Hypertension, Obesity