Effect of "Maccog" Tcm Tea On Improving Glucolipid Metabolism and Gut Microbiota in Patients With Type 2 Diabetes in Community

Authors

Biyue Hu
Tongtong Yin
Jiajia Zhang
Minjing Liu
Hang Yun
Jian Wang
Renmei Guo
Jie Huang
Yixia Zhou
Hongyan Meng
Li Wang

Publication Date

1-1-2023

Journal

Frontiers in Endocrinology

Abstract

OBJECTIVES: This work aimed to observe the effect of consuming Chinese herb tea on glucolipid metabolism and gut microbiota in patients with type 2 diabetes mellitus (T2DM).

METHODS: Ninety patients with T2DM were recruited from a community and randomly divided into the control group (CG) and intervention group (IG). CG maintained conventional treatment and lifestyle, and IG accepted additional "maccog" traditional Chinese medicine (TCM) tea (mulberry leaf, radix astragali, corn stigma, cortex lycii, radix ophiopogonis, and gynostemma) for 12 weeks. Glucolipid metabolism, hepatorenal function, and gut microbiota were then measured.

RESULTS: After the intervention, the decreases in fasting plasma glucose (FPG) and total cholesterol (TC) were greater (P

CONCLUSIONS: Administration of "maccog" TCM tea for 12 weeks slightly improved glucolipid metabolism and significantly increased the abundance of beneficial gut microbiota in community patients with T2DM. The increase in beneficial bacteria abundance may be involved in the improvement of glucose metabolism indicators. In addition, this intervention is safe and feasible.

CLINICAL TRIAL REGISTRATION: https://www.chictr.org.cn/showproj.aspx?proj=31281, identifier ChiCTR1800018566.

Keywords

Humans, Diabetes Mellitus, Type 2, Medicine, Chinese Traditional, Gastrointestinal Microbiome, Liver, Bacteria, Actinobacteria, Tea