Causal association Between Gut Microbiomes and Different Types of aneurysms: a Mendelian Randomization Study

Authors

Youjia Qiu
Yucheng Hou
Xingzhou Wei
Menghan Wang
Ziqian Yin
Minjia Xie
Aojie Duan
Chao Ma
Ke Si
Zhong Wang

Publication Date

1-1-2024

Journal

Frontiers in Microbiology

Abstract

BACKGROUND: Previous studies suggests that gut microbiomes are associated with the formation and progression of aneurysms. However, the causal association between them remains unclear.

METHODS: A two-sample Mendelian randomization was conducted to investigate whether gut microbiomes have a causal effect on the risk of intracerebral aneurysm (IA), thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA), and aortic aneurysm (AA). Single nucleotide polymorphisms (SNPs) smaller than the locus-wide significance level (1 × 10

RESULTS: The phylum

CONCLUSION: Our MR analysis confirmed the causal association of specific gut microbiomes with AAA, and these microbiomes were considered as protective factors. Our result may provide novel insights and theoretical basis for the prevention of aneurysms through regulation of gut microbiomes.

Keywords

Mendelian randomization, abdominal aortic aneurysm, aneurysms, genetic association, gut microbiome