The HCOA was formed in 1988 by the generosity of the late ">Roy M. and Phyllis Gough Huffington, Houston philanthropists who foresaw the need for an academic entity devoted to studying aging, providing care for older people, and teaching future health professionals and researchers about geriatrics and gerontology.
The Roy M. and Phyllis Gough Huffington Center on Aging spearheads breakthrough research and is committed to translating basic research discoveries into applications that promote healthy aging and combat age-associated disorders. The faculty, along with their research staff and trainees, utilize diverse model systems and multidisciplinary approaches to address questions that are of crucial importance to the biology, pathophysiology and diseases of aging. The major research topics include lifespan and health span studies, aging of the endocrine, vasculature, and central nervous systems, cancer, and neurodegenerative diseases, in particular Alzheimer’s disease..
Submissions from 2025
Clonal Dynamics and Somatic Evolution of Haematopoiesis in Mouse, Chiraag D Kapadia, Nicholas Williams, Kevin J Dawson, et al.
Development and Implementation of a Personal Virtual Assistant for Patient Engagement and Communication in Postsurgical Cancer Care: Feasibility Cohort Study, Miguel Bargas-Ochoa, Alejandro Zulbaran-Rojas, M G Finco, et al.
DNMT3A Regulates Murine Megakaryocyte-Biased Hematopoietic Stem Cell Fate Decisions, Sarah M Waldvogel, Virginia Camacho, Dandan Fan, et al.
Haploinsufficiency of ITSN1 Is Associated With a Substantial Increased Risk of Parkinson’s Disease, Thomas P Spargo, Chloe F Sands, Isabella R Juan, et al.
Inhibition of Soluble Epoxide Hydrolase Confers Neuroprotection and Restores Microglial Homeostasis in a Tauopathy Mouse Model, Shuo Wang, Chuangye Qi, Chetan Rajpurohit, et al.
Longitudinal Multi-Omics in Alpha-Synuclein Drosophila Model Discriminates Disease- From Age-Associated Pathologies in Parkinson’s Disease, Justin Moore, Timothy Wu, Justin Dhindsa, et al.
Modeling Functional Connectivity With Learning and Memory in a Mouse Model of Alzheimer’s Disease, Lindsay Fadel, Elizabeth Hipskind, Steen E Pedersen, et al.
Multi-Omics Delineate Growth Factor Network Underlying Exercise Effects in an Alzheimer’s Mouse Model, Xin Li, Chaozhong Liu, Wenbo Li, et al.
NKAPL Facilitates Transcription Pause-Release and Bridges Elongation to Initiation During Meiosis Exit, Zhenlong Kang, Chen Xu, Shuai Lu, et al.
Quantitative Profiling pH Heterogeneity of Acidic Endolysosomal Compartments Using Fluorescence Lifetime Imaging Microscopy, Dinghuan Deng, Youchen Guan, Ayse Sena Mutlu, et al.
Rewired m6A of Promoter Antisense RNAs in Alzheimer’s Disease Regulates Neuronal Genes in 3D Nucleome, Benxia Hu, Yuqiang Shi, Feng Xiong, et al.
Robotic First Rib Resection With Adjuvant Endovascular Therapy for Chronic Paget-Schroetter Syndrome, Alejandro Zulbaran-Rojas, Miguel Montero-Baker, Nihanth Palivela, et al.
The Dialysis Foot- the Impact of Presenting Estimated Glomerular Filtration Rate on Clinical Outcomes in Patients Hospitalized With Diabetic Foot Infections, Arthur Tarricone, Tyler L Coye, Allen Gee, et al.
The HAVCR1-Centric Host Factor Network Drives Zika Virus Vertical Transmission, Wenzhe Yu, Jun Tao, Hongmin Cao, et al.
The Infected Diabetic Foot: Bacteraemia and Endocarditis Complicating Moderate and Severe Foot Infections, Mario C Reyes, Arthur N Tarricone, Mathew J Sideman, et al.
The Infected Diabetic Foot: Incidence and Risk Factors for Dehiscence After Surgery for Diabetic Foot Infections, Lawrence A Lavery, Mario C Reyes, Bijan Najafi, et al.
Zika Virus NS1 Drives Tunneling Nanotube Formation for Mitochondrial Transfer and Stealth Transmission in Trophoblasts, Rafael T Michita, Long B Tran, Steven J Bark, et al.
Submissions from 2024
Advances in Immunocompetent Mouse and Rat Models, Wen Bu and Yi Li
A Light-Responsive Neural Circuit Suppresses Feeding, Hailan Liu, Na Qu, Natalia Valdez Gonzalez, et al.
Alzheimer's Disease Risk Gene CD2AP Is a Dose-Sensitive Determinant of Synaptic Structure and Plasticity, Taeyong Ahn, Gabrielle E Largoza, Julia Younis, et al.
Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells, Mary Elise L Severino, Lauren Richardson, Ananth Kumar Kammala, et al.
COVID-19 Convalescent Plasma Therapy: Long-Term Implications, Hyunah Yoon, Yi Li, Keith S Goldfeld, et al.
Cyclophilin a Supports Translation of Intrinsically Disordered Proteins and Affects Haematopoietic Stem Cell Ageing, Laure Maneix, Polina Iakova, Charles G Lee, et al.
Dawn-to-Dusk Dry Fasting Decreases Circulating Inflammatory Cytokines in Subjects With Increased Body Mass Index, Zahraa Al Lami, Miray Kurtca, Moin Uddin Atique, et al.
Diabetes Technology Meeting 2023, Tiffany Tian, Rachel E Aaron, Ashley Y DuNova, et al.