Pharmacological Management of Disease by Overcoming Structural Adversity

Authors

Richard N Sifers

Publication Date

1-19-2023

Journal

Cell Chemical Biology

DOI

10.1016/j.chembiol.2022.12.008

PMID

36669468

Published Open-Access

yes

Keywords

Proteostasis, Proteins, DNA

Abstract

In this issue of Cell Chemical Biology, Sun et al. utilize computational and protein expression analyses, plus pharmacological proteostasis network activation, to simultaneously correct two genetic diseases linked to a single protein rather than modify the responsible DNA.