Publication Date
8-1-2023
Journal
The FASEB Journal
PMID
37489832
PMCID
PMC10372848
PubMedCentral® Posted Date
8-1-2024
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Keywords
Humans, Female, Animals, Mice, Chromatin, Progesterone, Uterus, Endometrium, Endometrial Neoplasms, Chromatin, uterus, progesterone, estrogen, puberty
Abstract
Receptors for estrogen and progesterone frequently interact, via Cohesin/CTCF loop extrusion, at enhancers distal from regulated genes. Loss-of-function CTCF mutation in >20% of human endometrial tumors indicates its importance in uterine homeostasis. To better understand how CTCF-mediated enhancer-gene interactions impact endometrial development and function, the Ctcf gene was selectively deleted in female reproductive tissues of mice. Prepubertal Ctcf
Graphical Abstract
Included in
Biological Phenomena, Cell Phenomena, and Immunity Commons, Life Sciences Commons, Medical Cell Biology Commons, Medical Microbiology Commons, Medical Molecular Biology Commons, Obstetrics and Gynecology Commons, Oncology Commons